What does the term 'calibration' refer to in the context of nuclear medicine?

In the context of nuclear medicine, calibration specifically refers to the process of setting measurement instruments to a known standard. This is essential to ensure accuracy in the quantitative measurements taken during diagnostic procedures. Calibration involves comparing the output of a measurement instrument against a standard reference to identify any discrepancies and make necessary adjustments. This process is crucial because accurate measurement is fundamental for providing reliable diagnostic information, which directly influences patient care and treatment.

The other options pertain to different aspects of nuclear medicine. Adjusting imaging parameters for different patients involves tailoring the imaging settings to individual characteristics but does not relate directly to calibration. Determining the expiration date of radiopharmaceuticals is important for ensuring the safety and effectiveness of treatments but doesn't involve calibration. Establishing safety protocols for handling radioactive materials is vital for ensuring the safety of healthcare workers and patients, yet it is distinct from the accuracy adjustments made during calibration.