What is the recommended particle size for macroaggregated albumin?

The recommended particle size for macroaggregated albumin specifically states that 90% of the particles should fall between 10 and 90 micrometers. This range is critical because it ensures the macroaggregated albumin behaves as intended in various diagnostic and therapeutic applications. Particles that are too small may not adequately achieve the desired targeting or localization effect in the vascular system, whereas particles that are too large could lead to blockage of small blood vessels, potentially resulting in adverse effects.

The specified range of 10 to 90 micrometers also supports optimal performance of macroaggregated albumin in scenarios like radionuclide imaging and treatment of conditions such as pulmonary embolism. In summary, adherence to this particle size recommendation is essential to ensure safety, efficacy, and reliability in clinical applications of macroaggregated albumin.